When a nerve impulse arrives at a 5-HT or noradrenaline nerve terminal the neurotransmitter is released from the synaptic vesicle into the synaptic cleft. Neurotransmitter molecules bind to their specific receptors on the post-synaptic membrane and the nerve impulse is propagated or inhibited, depending on the receptor type. 5-HT and noradrenaline molecules are then released from their receptors and taken back into the nerve terminal via either the 5-HT or noradrenaline re-uptake transporters. 5-HT and noradrenaline are degraded by monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT), these enzymes are found in the nerve terminal.
Permissions for creative use of the resources from Neurotorium
Permission is granted to download images, slides and videos and use them in your own presentations, provided that copyright notices and the Neurotorium logo are not hidden or removed. For use in publications and on websites, proper attribution must be provided together with a link to Neurotorium.org