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AD and agitation figs 1-6 – slide 1
Hypothetical model for the pathological–clinical continuum of Alzheimer’s disease

The slide represents a hypothetical model for the pathological-clinical continuum of AD.[Sperling et al., 2011] The ‘preclinical’ stage precedes mild cognitive impairment (MCI) and includes individuals who have evidence of early AD pathological changes, but do not meet clinical…

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AD and agitation figs 1-6 – slide 2
What is Alzheimer’s disease?

Alzheimer’s disease (AD) is the most common cause of dementia, accounting for approximately 60–80% of all dementia cases.[Alzheimer’s Association, 2016] AD is a degenerative and progressive disorder, associated with cognitive, functional and behavioral symptoms.[Alzheimer’s Association, 2016] The most common…

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AD and agitation figs 1-6 – slide 3
Accumulation of Alzheimer’s disease risk factors over time

The risk factors and protective factors for the development of AD/dementia accumulate over a lifetime, as shown in this slide.[Jiang et al., 2013; Bendlin et al., 2010; Winblad et al., 2016] Many risk and protective factors for dementia and…

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AD and agitation figs 1-6 – slide 4
Examples of symptoms of Alzheimer’s disease

In general, the symptoms of AD can be divided into three categories – cognitive, functional, and neuropsychiatric. Cognitive symptoms – the main areas of cognition that can be impaired over the course of AD include memory, language, attention and…

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AD and agitation figs 1-6 – slide 5
Projected increase in the prevalence of Alzheimer’s disease

Worldwide, in 2015, an estimated 46.8 million people were living with dementia.[WHO, 2015] In the US, in 2016, an estimated 5.2 million people >65 years of age were affected by AD.[Hebert et al., 2013] Age is one of the…

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AD and agitation figs 1-6 – slide 6
Current approaches to AD management

Full reference details: American Psychiatric Association; Rabins PV, Rovner BW, Rummans T, et al. Guideline watch for the practice guideline for the treatment of patients with Alzheimer’s disease and other dementias. October 2014. APA Work Group on Alzheimer’s Disease…

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AD and agitation figs 1-6 – slide 7
Psychosocial therapies for AD

Full reference details: American Psychiatric Association; Rabins PV, Rovner BW, Rummans T, et al. Guideline watch for the practice guideline for the treatment of patients with Alzheimer’s disease and other dementias. October 2014. APA Work Group on Alzheimer’s Disease…

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