Alzheimer’s Disease – Comorbidity

The slide presents an overview of various pre-existing medical conditions that are associated with Alzheimer’s disease. The presentation covers the progression of Schizophrenia and functional decline.

The slide presents an overview of various pre-existing medical conditions that are associated with AD.

There is a good body of evidence to support an association between traumatic brain injury (TBI), diabetes, and depression with an increased risk of…

The slide presents an overview of the various modifiable lifestyle factors that are associated with AD.

There is evidence to suggest that moderate coffee consumption, physical activity, and cognitive activity, all play a preventative role in AD.^{[Jiang et al.,…}

This study a was population-based retrospective cohort study using the Clinical Practice Research Datalink, which provides anonymised data from the electronic health records of 674 primary care practices in the UK.^{[Browne et al., 2017]} The study included a total…

This study was a retrospective, nested case-control study, using a random sample of claims data from 2 million Taiwanese people between 2001–2011.^{[Wang et al., 2018]} In order to establish whether the risks of certain comorbidities were greater than normal…

The costs associated with the comorbidities of AD have been studied in various healthcare systems, including the additional caregiving costs.^{[Browne et al., 2017; Hill et al., 2002; Kuo et al., 2008; Leon et al., 1998]}

It has long…

The assessment of neuropsychiatric symptoms in patients with dementia is challenging.^{[Cerejeira et al., 2012]} Assessment requires detailed information about a patient’s clinical history, their subjective experiences, and an objective rating of their behaviour.^{[Cerejeira et al., 2012]} To this end,…

AD and depression are thought to share some common risk factors, including inflammation.^{[Li et al., 2014]} However, the direction of the risk is poorly understood.^{[Li et al., 2014]} Does depression increase the risk of AD, or does dementia increase…

Generalised anxiety disorder (GAD) is characterised by excessive anxiety and worry, about numerous events or activities.^{[APA, 2013]} Examples include worrying about household chores, or being late for appointments.^{[APA, 2013]}

Methodologically, the study of symptoms of anxiety in patients with…

Although agitation is a common feature of dementia,^{[Gauthier et al., 2010; Margallo-Lana et al., 2001]} there was for a long time no consensus definition of agitation, and no widespread agreement on what elements should be included in the syndrome.^[Cummings…

A methodological challenge to studying the interaction of dementia and bipolar disease, is the fact that many studies of dementia and depression are poorly controlled for bipolar disorder – it is possible that, in many of the studies, the depression…

The study of sleep disturbances in AD is complicated by the still incomplete understanding of the normal functions of sleep in a non-pathological context.^{[Cipriani et al., 2015]} The aetiology of the sleep disorders seen in dementia appears to be…

A large scale anonymous survey of the carers of patients with dementia in Germany, Poland, France, and the UK was published in 2008, questioning people about the burden of caring for individuals with dementia.^{[Georges et al., 2008]} In total,…