Alzheimer’s Disease – Epidemiology and Burden

This presentation is a comprehensive overview of the epidemiology and burden of Alzheimer’s Disease. It summarises the causes, risk factors, prevalence and impact of the condition with strong visuals and supporting notes. 

AD has multifactorial etiology and is thought to result from many inter-related components, including genetic and environmental factors.

AD is classified according to the age of the person at onset – late-onset (≥65 years; most common form of AD)…

The slide presents an overview of various pre-existing medical conditions that are associated with AD.

There is a good body of evidence to support an association between traumatic brain injury (TBI), diabetes, and depression with an increased risk of…

The slide presents an overview of the various modifiable lifestyle factors that are associated with AD.

There is evidence to suggest that moderate coffee consumption, physical activity, and cognitive activity, all play a preventative role in AD.^{[Jiang et al.,…}

The risk factors and protective factors for the development of AD/dementia accumulate over a lifetime, as shown in this slide.^{[Jiang et al., 2013; Bendlin et al., 2010; Winblad et al., 2016]}

Many risk and protective factors for dementia and…

Many risk and protective factors for dementia and AD have been proposed and investigated; however, the evidence to support the factors listed on this slide is variable, and the relevance of several proposed factors is open to debate.^{[Winblad et…}

Worldwide, in 2015, an estimated 46.8 million people were living with dementia.^{[WHO, 2015]} In the US, in 2016, an estimated 5.2 million people >65 years of age were affected by AD.^{[Hebert et al., 2013]} Age is one of the…

Three domains of AD feed into overall global function, all of which can increase the burden on caregivers.

• Cognitive function – higher mental processes such as memory, reasoning, attention, and language, that facilitate information gathering and processing.
• Activities…

AD has a considerable public health impact. In the US, in 2014, AD was listed as the sixth leading cause of death (based on ICD-10, G30 classification) for the total population, after heart disease, malignant neoplasms, chronic lower respiratory…

The pressure of AD on caregivers is highlighted on this slide. Information from the dementia carer’s survey shows that the time spent caring for people with dementia increases as the disease severity progresses.^{[Georges et al., 2008]} However, it is…

Full reference details: Alzheimer’s Association. 2016 Alzheimer’s disease facts and figures. Alzheimers Dement 2016; 12 (4): 459–509.

Georges J, Jansen S, Jackson J, et al. Alzheimer’s disease in real life – the dementia carer’s survey. Int J Geriatr Psychiatry 2008;…

Full reference details Alzheimer’s Association. 2016 Alzheimer’s disease facts and figures. Alzheimers Dement 2016; 12 (4): 459–509.

Georges J, Jansen S, Jackson J, et al. Alzheimer’s disease in real life – the dementia carer’s survey. Int J Geriatr Psychiatry 2008;…

Full reference details: Alzheimer’s Association. 2016 Alzheimer’s disease facts and figures. Alzheimers Dement 2016; 12 (4): 459–509.

Georges J, Jansen S, Jackson J, et al. Alzheimer’s disease in real life – the dementia carer’s survey. Int J Geriatr Psychiatry 2008;…

Full reference details: Alzheimer’s Association. 2016 Alzheimer’s disease facts and figures. Alzheimers Dement 2016; 12 (4): 459–509.

Georges J, Jansen S, Jackson J, et al. Alzheimer’s disease in real life – the dementia carer’s survey. Int J Geriatr Psychiatry…

Full reference details Alzheimer’s Association. 2016 Alzheimer’s disease facts and figures. Alzheimers Dement 2016; 12 (4): 459–509.

Georges J, Jansen S, Jackson J, et al. Alzheimer’s disease in real life – the dementia carer’s survey. Int J Geriatr Psychiatry…

AD is a complex disease of multifactorial etiology that, despite a wealth of clinical research, is not yet completely understood. Among various genetic and environmental factors implicated in AD, age is the most important risk factor for the disease.…