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Study involved 25 adult outpatients diagnosed with schizophrenia (n=18) or schizoaffective disorder (n=7), documented by a checklist of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria, taking a single oral antipsychotic medication.
The antipsychotic adherence of patients was monitored at 3 monthly assessments with the MEMS, a medication vial cap that electronically records the date and time of bottle opening.
Patients were determined to meet criteria for daily adherence, as assessed by the MEMS cap, if they opened their bottle the prescribed number of times per day, irrespective of the time of bottle opening.
A patient was deemed nonadherent if during any single month the MEMS recordings revealed that the bottle was opened <70% of the requisite prescribed occasions.
The Clinician Rating Scale is an ordinal scale of 1-7, with higher numbers equaling greater adherence. The authors chose a priori to employ a score of ≤4 at any 1 of the 3 monthly evaluations as the threshold for clinically meaningful nonadherence.
Twelve patients (48.0%) were nonadherent as determined by the MEMS cap, while no patients were deemed nonadherent by the Clinician Rating Scale (P<0.0001).
Reference:
Byerly M, Fisher R, Whatley K, et al. A comparison of electronic monitoring vs. clinician rating of antipsychotic adherence in outpatients with schizophrenia. Psychiatry Res. 2005; 133(2-3): 129-133.
Study involved 25 adult outpatients diagnosed with schizophrenia (n=18) or schizoaffective disorder (n=7), documented by a checklist of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria, taking a single oral antipsychotic medication.
The antipsychotic adherence of patients was monitored at 3 monthly assessments with the MEMS, a medication vial cap that electronically records the date and time of bottle opening.
Patients were determined to meet criteria for daily adherence, as assessed by the MEMS cap, if they opened their bottle the prescribed number of times per day, irrespective of the time of bottle opening.
A patient was deemed nonadherent if during any single month the MEMS recordings revealed that the bottle was opened <70% of the requisite prescribed occasions.
The Clinician Rating Scale is an ordinal scale of 1-7, with higher numbers equaling greater adherence. The authors chose a priori to employ a score of ≤4 at any 1 of the 3 monthly evaluations as the threshold for clinically meaningful nonadherence.
Twelve patients (48.0%) were nonadherent as determined by the MEMS cap, while no patients were deemed nonadherent by the Clinician Rating Scale (P<0.0001).
Reference:
Byerly M, Fisher R, Whatley K, et al. A comparison of electronic monitoring vs. clinician rating of antipsychotic adherence in outpatients with schizophrenia. Psychiatry Res. 2005; 133(2-3): 129-133.