Hospitalization Costs due to Patient Nonadherence

Specific inputs from Gilmer et al.^{[Gilmer et al., 2004]} and Svarstad et al.^{[Svarstad et al., 2001]}—including nonadherence rate, rehospitalization rate, annual hospitalization costs associated with the use of antipsychotic drugs, and the daily hospital costs—were used to calculate total costs due to nonadherence in 2005. The daily hospital costs were extrapolated from National Inpatient Sample of Healthcare Cost and Utilization Project data in 2005.^{[Sun et al., 2007]}

Studies demonstrated that costs related to nonadherence ranged from $13922^{[Svarstad et al., 2001]} to $1826 million^{[Valenstein et al., 2002]} in 2005.

References:
Gilmer TP, Dolder CR, Lacro JP, et al. Adherence to treatment with antipsychotic medication and health care costs among Medicaid beneficiaries with schizophrenia. Am J Psychiatry. 2004; 161(4): 692-699.

Svarstad BL, Shireman TI, Sweeney JK. Using drug claims data to assess the relationship of medication adherence with hospitalization and costs. Psychiatr Serv. 2001; 52(6): 805-811.

Sun SX, Liu GG, Christensen DB, Fu AZ. Review and analysis of hospitalization costs associated with antipsychotic nonadherence in the treatment of schizophrenia in the United States. Curr Med Res Opin. 2007; 23(10): 2305-2312.

Valenstein M, Copeland LA, Blow FC, et al. Pharmacy data identify poorly adherent patients with schizophrenia at increased risk for admission. Med Care. 2002; 40(8): 630-639.