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Key message: Many patients experience symptoms that are not fully controlled with treatment, with social withdrawal and impoverished thought being the two most common negative symptoms, and disordered thought and bizarre behavior the two most common positive symptoms. Between 47–60% of patients experience positive symptoms that are not fully controlled by treatment.

Background

• In a large, multinational, cross-sectional survey, psychiatrists in the US and five European countries (France, Germany, Italy, Spain, and the United Kingdom) who prescribed antipsychotics for ≥15 patients with schizophrenia within the preceding 3 months, provided data on their patients’ demographic and clinical characteristics, their antipsychotic prescribing practices and drug attributes influencing treatment choice.
• Data were collected from 872 physicians on 6523 patients (85% European, 15% US). Most patients were aged 25–44 years, 63% were men, and 66% were outpatients.
• Inadequate control was reported more frequently for negative (71–77%) than positive (47–60%) symptoms.

Reference:
Lecrubier Y, et al. Eur Psychiatry. 2007; 22 (6): 371–379.