Agonists are drugs that mimic the effects of endogenous neurotransmitters. Inverse agonists are drugs that have the opposite action i.e. they have opposite effects to a neurotransmitter. Both agonist and inverse agonist effects are blocked by antagonists.
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Migraine is a prevalent neurological disorder characterized by recurrent and disabling attacks of moderate to severe headache
Migraine affects an estimated 1.1 billions worldwide and ranks as the 2nd leading cause of disability, while being the leading among young adults.
In human models of migraine, a suspected pharmacological migraine trigger is administered either orally or via infusion to a participant with migraine or a healthy volunteer, typically within a double-blinded, randomized, placebo-controlled design