Download Slide Decks on Parkinson’s Disease

Parkinson’s Disease (PD) is the second-most common neurodegenerative disorder, after Alzheimer’s Disease. PD is a chronic, progressive, neurodegenerative condition that mainly affects elderly people. The clinical effects of Parkinson’s Disease are visually obvious, but the underlying pathology of PD is still not fully understood. 

Get an introduction to Parkinson’s disease or dive into details on the subject by going through our slide decks. You can view and download slides individually or as a deck.

In each slide deck, you will encounter a topic introduction and delve into essential concepts related to Parkinson’s disease. Our slide decks encompass a variety of subjects, including genetic risk factors for Parkinson’s disease, the challenges of managing non-motor symptoms, and motor complications such as dyskinesia and motor fluctuations.

The slides have been created by experts specializing in Parkinson’s disease. Whether you are a student, educator, or simply someone interested in learning more about Parkinson’s disease, the slides are freely available for your use in classes, teaching, or exams.

History, Definitions, and Diagnosis

Parkinson’s disease is often diagnosed at the onset of motor symptoms. Yet, the diagnosis can be preceded by a long prodromal phase of 15 years or more. In this slide deck, the history of Parkinson’s disease is presented together with a description of the cardinal symptoms of the disease, diagnostic criteria, biomarkers and commonly used scales. Go to the slide deck.

Epidemiology and Burden

Parkinson’s disease is considered the second most common neurodegenerative disease, after Alzheimer’s disease. This presentation covers the prevalence of Parkinson’s Disease across different global regions and describes the substantial burden the disease places on the patient and caregivers. Go to the slide deck.

Course, Natural History, and Prognosis

Parkinson’s disease is a slowly progressing disease. The underlying pathology is not fully understood but is thought to spread from brain region to brain region over multiple long-distance relays, during long periods of time. Go to the slide deck. Go to the slide deck.

Non-motor Symptom Complex and Comorbidities

Non-motor symptoms are reported by nearly all patients with Parkinson’s disease. The symptoms include e.g., constipation, sleep disorders, cognitive impairment, mood disorders, olfactory dysfunction among other. In this slide deck, non-motor symptoms, quality of life and the comorbidities of Parkinson’s disease are discussed. Go to the slide deck.

Neurobiology and Aetiology

At a physiological level, PD is characterised by the loss of neurons in specific regions of the brain and a spreading of Lewy pathology. In early phases of the disease, α‑synuclein deposition has been associated with the appearance of non-motor symptoms, such as olfactory (smell) and autonomic (vital) dysfunction. This slide deck covers the neurobiology and aetiology of Parkinson’s disease. Go to the slide deck.

Treatment Principles

Levodopa and dopamine agonists play a major role in the treatment of Parkinson’s Disease. Levodopa is the key symptomatic treatment for the disease. Over time, patients may experience wearing of, where the duration of treatment response becomes progressively shorter. This slide deck presents common treatment approaches. Go to the slide deck.

Read Articles on Parkinson’s Disease

Our selected articles will delve into these facets of Parkinson’s disease, offering insights into the diverse nature of non-motor symptoms, their impact on patients, and the potential for improved management.

  • The microbiome-gut-brain axis in Parkinson’s disease
    Evidence has been accumulating over the past years for a bidirectional relationship between the brain and the gut that plays an important role in Parkinson’s disease (PD). Recent research suggests that the gut microbiome plays a key part in this relationship and that the microbiome-gut-brain axis can influence pathophysiological mechanisms involved in PD risk and progression.
  • Gastrointestinal dysfunction in Parkinson’s disease
    It is now well recognised that gastrointestinal symptoms, particularly constipation, are amongst the most prominent and troublesome early manifestations of PD. The fact that alpha-synuclein aggregations can be found in the gastrointestinal tract of patients with early or even prodromal PD lends weight to the idea that PD may start in the gut, at least in some patients.
  • Non-motor symptoms in Parkinson’s disease: nature and burden
    Over recent years, the impact of non-motor symptoms has gained increased attention. These symptoms are common, heterogeneous, and sometimes severe and disabling, and their more effective management is a major unmet need. Non-motor symptoms are given greater recognition in the latest Movement Disorders Society diagnostic and research criteria.

Watch the Videos on Parkinson’s Disease

Get insights on Parkinson’s disease through our videos. Understand the complexities of Parkinson’s Disease pathology and explore the mechanics of movement with The Brain Prize Explainer. Elevate your understanding with expertly curated content.

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Parkinson’s disease is the second most frequent neurodegenerative disorder of ageing after Alzheimer’s disease.

Parkinson’s disease is characterized by 4 cardinal motor symptoms: tremor at rest; rigidity; bradykinesia; and postural instability. This progressive disorder is also associated with cognitive, behavioural, and autonomic impairments causing increased disability and contributing to a loss of independence.

Download Illustrations & Figures on Parkinson’s Disease

View an illustration of the bidirectional interplay between the brain and the gut, involving pathways such as the vagus nerve and bloodstream. Factors contributing to Parkinson’s disease development encompass aging-related processes, alpha-synuclein aggregation and spread, the gut bacterial microbiome and its metabolic activities, gut barrier integrity, inflammation, environmental influences, host genetic factors, and possibly chance effects. See a schematic illustration depicting how the gut-brain axis may contribute to the spread of alpha-synuclein pathology below.

Schematic illustration of how the gut-brain axis may contribute to the spread of alpha-synuclein pathology
Bidirectional interplay between the brain and the gut includes the vagus nerve pathway, and non-vagus nerve pathways such as the bloodstream. Important factors associated with the development of PD include ageing-related processes, aggregation and spread of alpha-synuclein, gut bacterial microbiome and their metabolic activities, gut barrier disruption, inflammation, environmental influences, host genetic factors, and probably chance effects.
This picture illustrates potential non-motor features associated with Parkinson’s disease