The so-called ‘normative modeling’ can be used to model the expected development of a given characteristic across the lifespan. Deviations from this development can be tested for associations with clinical outcomes and may pinpoint illness-relevant effects at the individual subject level. By integrating multiple data modalities this approach may yield information on risk architectures that can be useful for personalized psychiatry.1
Related content
Summary of the physiological changes associated with reproductive aging and the potential links between the menopausal transition and mental health conditions.
This illustration shows key phases of ovarian hormone fluctuation across the female lifespan, from menarche to menopause.
Physiological changes in endocrine function from the reproductive stage to perimenopause