When a nerve impulse arrives at a noradrenaline nerve terminal, noradrenaline is released from synaptic vesicles into the synaptic cleft. Noradrenaline molecules bind to their receptors on the post-synaptic membrane and the nerve impulse is propagated or inhibited, depending on the specific receptor. Noradrenaline molecules are then released from their receptors and taken back into the nerve terminal via the noradrenaline re-uptake transporter. Noradrenaline is degraded by monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT).1,2
Related content
Suicidal ideation is far more common than attempts in people with anxiety or depression, especially with comorbid disorders and severe depression.
Anxiety disorders in Europe carry substantial costs, with PTSD and panic disorder leading, followed by social anxiety, GAD, and agoraphobia.