The principles and practical use of MEG.
Source. David Nutt, Imperial College London.
To study intra-disease variability in cognitive function, researchers employ data-driven clustering methods to differentiate patients with widespread cognitive abnormalities from patients who are cognitively intact.
Bipolar disorder is associated with marked clinical and phenotypic heterogeneity, including differences in symptomatology, medical and psychiatric comorbidities, and neurocognitive function. Intra- and inter-individual differences increase the complexity of the disorder, which complicates accurate diagnosis, management.
Depressive predominant polarity is typically defined as having at least two-thirds of lifetime episodes being depressive, whereas manic predominant polarity refers to at least two-thirds of prior episodes being (hypo)manic episodes. Studies show that predominant polarity has prognostic value and clinical and therapeutic implications.