Schizophrenia - Comorbidity

Schizophrenia is a chronic mental health condition that comprises positive symptoms, negative symptoms, motor symptoms, and a global cognitive deficit. In 2019, schizophrenia ranked as the 20^thleading cause of disability globally; affected individuals experience a reduction in life expectancy of 15 years or more. Alongside disease burden, individuals with schizophrenia experience a range of psychiatric and somatic comorbidities. Schizophrenia is reportedly associated with more than 1.5 times the odds of comorbidities across multiple disease categories, and is linked to broad, multi‑system increases in natural‑cause mortality^.

This slide deck was developed by Professor Dr. Merete Nordentoft, Department of Clinical Medicine, University of Copenhagen, Denmark; and Professor Dr. Christoph Correll, Charité – Universitätsmedizin Berlin, Germany, in collaboration with Cambridge (a division of Prime, Cambridge, UK).

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Schizophrenia’s hidden genetic relationships

The authors of this study concluded that the current clinical boundaries between major psychiatric disorders do not reflect distinct underlying genetic aetiologies; many psychiatric disorders, including schizophrenia, share large portions of common variant risk.¹ The obse…

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Enriched phenotypes preceding a diagnosis of schizophrenia

Reference:
1. Lu C, Jin D, Palmer N, et al. Large-scale real-world data analysis identifies comorbidity patterns in schizophrenia. Transl Psychiatry 2022; 12: 154.

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Enriched phenotypes succeeding a diagnosis of schizophrenia

Reference:
1. Lu C, Jin D, Palmer N, et al. Large-scale real-world data analysis identifies comorbidity patterns in schizophrenia. Transl Psychiatry 2022; 12: 154.

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Incidence and timing of psychiatric comorbidities in schizophrenia

Reference:
1. Krebs MD, Themudo GE, Benros ME, et al. Associations between patterns in comorbid diagnostic trajectories of individuals with schizophrenia and etiological factors. Nat Commun 2021; 12: 6617.

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Timing of psychiatric comorbidities in schizophrenia

The figure presents a matrix of HRs showing how receiving one psychiatric diagnosis affects the risk of subsequently receiving another among 5,432 individuals with schizophrenia.¹ This analysis captures temporal ordering, that is, which comorbidities tend to appear before…

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