Index for
slide deck
Title
-485x272-c-center.jpg)
Definitions and Diagnosis
Definitions
-485x272-c-center.jpg)
Definitions
-485x272-c-center.jpg)
Schizophrenia: a definition
-485x272-c-center.jpg)
Schizophrenia: a definition (cont’d)
-485x272-c-center.jpg)
The trajectory to schizophrenia – evolution of symptoms and main risk factors
-485x272-c-center.jpg)
Negative Symptoms: something is “missing”
-485x272-c-center.jpg)
Positive Symptoms: Hallucinations
-485x272-c-center.jpg)
Delusions
What is optimal functioning for a patient with schizophrenia?
-485x272-c-center.jpg)
What is optimal functioning for a patient with schizophrenia?
-485x272-c-center.jpg)
Take home points

Functioning is complex and multifactorial
Functioning is complex and multifactorial, and there are many different domains of function e.g. social, everyday, community and psychological functioning, some which are defined on this slide.
Background
Definitions of the various types of functioning have…
-485x272-c-center.jpg)
A variety of factors contribute to functional impairment in patients with schizophrenia
Please note, this slide builds.
Key message: A variety of factors contribute to impairment in everyday functioning in patients with schizophrenia, including functional capacity, social cognition, symptoms, environmental factors, and health status.
-
The figure on this slide shows…
-485x272-c-center.jpg)
Multiple measures of patient functioning exist, but may not always help to understand the impact on the patient1
Key message: Although many measures of functioning exist, little is known about how these measures help to understand the impact of functional impairment.[Wilson C et al., 2016]
- To comprehensively evaluate functional outcome in schizophrenia, a combination of performance-based and…
-485x272-c-center.jpg)
Quality of life can be measured using different scales
Key message: Quality of life can be measured using different scales.
Background Heinrichs-Carpenter Quality of Life Scale (QLS).[Bilker et al., 2003; Cramer et al., 2001]
- The QLS balances subjective questions regarding life satisfaction and occupational role functioning.
- It consists of…
-485x272-c-center.jpg)
Patients may have functional goals that are personal and meaningful to them
Goal-setting helps patients focus on improving their daily lives, and accomplishing these goals provides a sense of satisfaction and success.[Med-IQ, 2014]
Reference: Med IQ. Goal-Setting Worksheet for People with Schizophrenia. Available at: http://www.mediq.com/files/noncme/material/pdfs/
-485x272-c-center.jpg)
Patients may have functional goals that are personal and meaningful to them
Key message: Better social and occupational functioning are consistently identified as important self-defined treatment goals, and improved functioning may be the most meaningful and valued outcome of treatment from a patient and family perspective.[Bellack et al., 2007]
Background
- In an…

Patients with schizophrenia experience motivation deficits
Key message: People with schizophrenia more often refer to their goals as being driven by boredom or a desire to ‘pass time’ and report goals that are more disconnected–disengaged compared with those of healthy controls.[Gard et al., 2014]
- Patients…
-485x272-c-center.jpg)
Motivation deficits significantly predict poor functional outcomes in early schizophrenia
Key message: Motivational deficits are prevalent in patients with schizophrenia, and correlate significantly with each domain of functioning examined (global functional outcome, social functioning, role functioning, and number of days worked in the past 30 days). These deficits are prevalent…
-485x272-c-center.jpg)
Current treatment guidelines include optimizing functioning and quality of life as important treatment goals
Note, this slide contains builds. Goals 2 and 3 change colour to red as these are the most relevant to the focus of the deck.
Current treatment guidelines include optimizing functioning and quality of life as important treatment goals,…
-485x272-c-center.jpg)
Health-related quality of life encompasses many variables
Key message: Health-related quality of life is complex and encompasses functional abilities, well-being, social interaction, vocational status, and physical and psychological state.
Background[Cramer et al., 2000]
-
Assessment of health-related quality of life (HRQoL) has become an important aspect in…