Articles

Current evidence on the neurobiology of addictive behaviour highlights the transition from reward-driven to habitual drug use through alterations in mesolimbic dopamine, glutamatergic signalling, frontostriatal circuitry, and stress-related systems.

Decades of twin and family research have established that anxiety disorders run in families and are meaningfully influenced by genetic factors. Family and twin studies suggest an increased recurrence risk for first degree relatives of patients with anxiety to develop any anxiety disorders.

Physical health and mental disorders are closely linked, with mental–physical comorbidity posing a major global public health and equity challenge.

Summary of the physiological changes associated with reproductive aging and the potential links between the menopausal transition and mental health conditions.

Psychiatric comorbidities such as depression, anxiety and psychosis are highly prevalent in persons with epilepsy, profoundly influencing quality of life, seizure outcomes, and mortality.

The exposome reframes dementia as the product of cumulative physical and social exposures-like pollution, nutrition, and inequality-across life. These factors shape brain aging through inflammation and epigenetic change. Lifespan, global studies are key to equitable dementia prevention.