Articles

Physical health and mental disorders are closely linked, with mental–physical comorbidity posing a major global public health and equity challenge.

Summary of the physiological changes associated with reproductive aging and the potential links between the menopausal transition and mental health conditions.

Psychiatric comorbidities such as depression, anxiety and psychosis are highly prevalent in persons with epilepsy, profoundly influencing quality of life, seizure outcomes, and mortality.

The exposome reframes dementia as the product of cumulative physical and social exposures-like pollution, nutrition, and inequality-across life. These factors shape brain aging through inflammation and epigenetic change. Lifespan, global studies are key to equitable dementia prevention.

Fear, rejection, and “othering” of people living with epilepsy continues to be a major additional burden, a burden beyond seizures, for many people globally.

The complex interplay between metabolic dysfunction and brain insulin resistance in schizophrenia warrants further investigation as it represents a unique opportunity for both mechanistic inquiry and the development of novel therapeutic strategies that can improve metabolic and cognitive outcomes in this population.