Noradrenaline binding to α2 noradrenaline receptor inhibits noradrenaline release. The α2 noradrenaline receptor is coupled to inhibitory G-proteins. Following agonist binding, the G-protein dissociates from the receptor and inhibits adenylyl cyclase. This causes the inactivation of adenylyl cyclase, resulting in a decrease of cyclic adenosine monophosphate (cAMP) produced from ATP. As cAMP is inhibited, potassium efflux through calcium-activated channels prevents calcium ions from entering the nerve terminal, leading to hyperpolarization and a suppression of neural firing and neurotransmitter release.
Permissions for creative use of the resources from Neurotorium
Permission is granted to download images, slides and videos and use them in your own presentations, provided that copyright notices and the Neurotorium logo are not hidden or removed. For use in publications and on websites, proper attribution must be provided together with a link to Neurotorium.org