This slide deck summarizes the current knowledge surrounding the use of psychedelics for the treatment of depression. Specifically, our focus centers on serotonergic psychedelics, commonly referred to as classical psychedelics. These psychedelics primarily function as agonists or partial agonists at the serotonin 2A receptor (5-HT2A receptor).

This slide deck has been developed with Professor Gitte Moos Knudsen, University of Copenhagen, Denmark, and Professor David Nutt, Imperial College London, UK, and in collaboration with Cambridge (a division of Prime, Cambridge, UK).

Index for
slide deck

Introduction

Psychedelics Fact Sheet slide1
A short summary of what we know todaya on classical psychedelics for the treatment of depression
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Psychedelic fact sheet

Psychedelics Fact Sheet slide4
Fact 1: 5-HT2A receptor binding

References:
1. CAS Common chemistry. Serotonin. Available at: https://commonchemistry.cas.org/detail?cas_rn=50-67-9&search=serotonin. Accessed 11 Oct 2023.

2. CAS Common chemistry. (+)-Lysergic acid diethylamide. Available at: https://commonchemistry.cas.org/detail?cas…

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Psychedelics Fact Sheet slide5
Fact 2: Changes in default mode network

References:
1. University of California San Francisco (UCSF). Psilocybin rewires the brain for people with depression. Available at: https://www.ucsf.edu/news/2022/04/422606/psilocybin-rewires-brain-people-depression. Accessed 21 October 2023.

2. Daws RE, Timmermann C,…

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