The distinction between episodic and chronic migraine is made when a person crosses a threshold of 15 monthly headache days, 8 of which meet the criteria for migraine.1 The division between episodic and chronic is therefore based on the frequency of the migraine symptoms.1 People with chronic migraine typically have worse disease outcomes, a more severe disease, and greater use of healthcare resources.2
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Migraine is a prevalent neurological disorder characterized by recurrent and disabling attacks of moderate to severe headache
Migraine affects an estimated 1.1 billions worldwide and ranks as the 2nd leading cause of disability, while being the leading among young adults.
In human models of migraine, a suspected pharmacological migraine trigger is administered either orally or via infusion to a participant with migraine or a healthy volunteer, typically within a double-blinded, randomized, placebo-controlled design