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This study used a database sample of >600,000 individuals to determine the incidence of liver diseases in patients with schizophrenia compared with the general population.[Hsu et al., 2014] For the purposes of the study, chronic liver disease included: alcoholic fatty liver, acute alcoholic hepatitis, alcoholic cirrhosis of the liver, alcoholic liver damage, unspecified, chronic hepatitis, cirrhosis of the liver without mention of alcohol, biliary cirrhosis, other chronic non-alcoholic liver diseases, and unspecified chronic liver disease without mention of alcohol.[Hsu et al., 2014] An odds ratio of 1.27 was found, indicating that patients with schizophrenia have a heightened risk of liver diseases, however, in patients aged 18–29 the odds ratio was 1.90.[Hsu et al., 2014] A consistent theme, when discussing the comorbidities of schizophrenia, these results highlight the importance of detection of liver diseases in patients with schizophrenia, so that treatment can be given as early as possible.[Hsu et al., 2014]
References:
Hsu JH, Chien IC, Lin CH, et al. Increased risk of chronic liver disease in patients with schizophrenia: a population-based cohort study. Psychosomatics 2014; 55 (2): 163–171.
Morlán-Coarasa MJ, Arias-Loste MT, Ortiz-García de la Foz V, et al. Incidence of non-alcoholic fatty liver disease and metabolic dysfunction in first episode schizophrenia and related psychotic disorders: a 3-year prospective randomized interventional study. Psychopharmacology (Berl) 2016; 233 (23–24): 3947–3952.