Monoamine oxidase B (MAOB) is an enzyme involved in the metabolism of dopamine. It converts dopamine to its corresponding carboxylic acid via an aldehyde intermediate. MAOB regulates both the free intraneuronal concentration of dopamine and the releasable stores. MAOB inhibitors bind to and inhibit MAOB, preventing dopamine degradation. This results in greater stores of dopamine available for release. MAOB inhibitors are used in the treatment of depression. People with depression have higher levels of the brain protein MAOB than people without depression.
Click here: Learn about the role of MAO-B inhibitors in depression treatment
Related content
This slide deck offers a comprehensive overview of Major Depressive Disorder (MDD), including its definitions, diagnostic criteria, symptom profiles, clinical course, differential diagnoses, and validated rating tools based on DSM-5-TR and ICD-11 guidelines.
This slide deck covers the treatment principles of Major Depressive Disorder (MDD).
This slide deck covers the course, natural history, and prognosis of Major depressive disorder (MDD)