Major Depressive Disorder – Treatment Principles

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Slide description

The optimal outcome for a patient with major depressive disorder is a full recovery from the major depressive episode and to never become depressed again.

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The best outcome for a patient with major depressive disorder (MDD) is a full recovery from the major depressive episode and never to become depressed again. The treatment of MDD is divided into three phases, corresponding to the different stages of the illness. This slide deck includes infographic slides and figures illustrating the treatment principles of MDD, such as pharmacotherapy and non-pharmacological therapies. In addition, you will find information about the adverse effects of pharmacological treatment and unmet needs in the treatment of depression. Last, the slides present an introduction to guidelines for and a global approach to treating depression.

This slide deck has been developed in collaboration with the former Lundbeck International Neuroscience Foundation.

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slide deck

Introduction

Major Depressive Disorder – Treatment Principles – slide 1

Treatment principles

The optimal outcome for a patient with major depressive disorder is a full recovery from the major depressive episode and to never become depressed again.

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Major Depressive Disorder – Treatment Principles – slide 2

Goals of treatment

The optimal outcome for a patient with major depressive disorder (MDD) is a full recovery from the major depressive episode and to never become depressed again.^{[Nierenberg & DeCecco, 2001]} Treatment of MDD is divided into three phases, corresponding to different…

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Treating depression – non-pharmacological therapies

Major Depressive Disorder – Treatment Principles – slide 3

Treating depression – non-pharmacological therapies

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Major Depressive Disorder – Treatment Principles – slide 4

Non-pharmacological therapy for depression

There are many non-pharmacological approaches to the treatment of depression. Some of those approaches are summarised in these slides.

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Major Depressive Disorder – Treatment Principles – slide 5

Psychotherapy – behavioural therapy

Non-pharmacological therapy options comprise psychotherapies and brain stimulation methods. Psychotherapies may be used together with antidepressants.^{[Sadock et al., 2009]}

Generally, there is a lack of evidence surrounding the use of non-pharmacological therapies for MDD – few well-controlled studies have been…

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Major Depressive Disorder – Treatment Principles – slide 6

Psychotherapy – interpersonal psychotherapy

Non-pharmacological therapy options comprise psychotherapies and brain stimulation methods. Psychotherapies may be used together with antidepressants.^{[Sadock et al., 2009]}

Generally, there is a lack of evidence surrounding the use of non-pharmacological therapies for MDD – few well-controlled studies have been…

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Major Depressive Disorder – Treatment Principles – slide 7

Psychotherapy – group therapy

Non-pharmacological therapy options comprise psychotherapies and brain stimulation methods. Psychotherapies may be used together with antidepressants.^{[Sadock et al., 2009]}

Generally, there is a lack of evidence surrounding the use of non-pharmacological therapies for MDD – few well-controlled studies have been…

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Major Depressive Disorder – Treatment Principles – slide 8

Psychotherapy – cognitive-behavioural therapy (CBT)

Non-pharmacological therapy options comprise psychotherapies and brain stimulation methods. Psychotherapies may be used together with antidepressants.^{[Sadock et al., 2009]}

Generally, there is a lack of evidence surrounding the use of non-pharmacological therapies for MDD – few well-controlled studies have been…

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Major Depressive Disorder – Treatment Principles – slide 9

Psychotherapy – mindfulness-based cognitive therapy (MBCT)

Non-pharmacological therapy options comprise psychotherapies and brain stimulation methods. Psychotherapies may be used together with antidepressants.^{[Sadock et al., 2009]}

Generally, there is a lack of evidence surrounding the use of non-pharmacological therapies for MDD – few well-controlled studies have been…

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Major Depressive Disorder – Treatment Principles – slide 10

Brain stimulation methods – electroconvulsive therapy (ECT)

Other than psychotherapy, non-pharmacological therapy options for the treatment of MDD include brain stimulation methods, such as electroconvulsive therapy (ECT), vagus nerve stimulation (VNS), and transcranial magnetic stimulation (TMS). The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for…

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Major Depressive Disorder – Treatment Principles – slide 11

Brain stimulation methods – vagus nerve stimulation (VNS)

Other than psychotherapy, non-pharmacological therapy options for the treatment of MDD include brain stimulation methods, such as electroconvulsive therapy (ECT), vagus nerve stimulation (VNS), and transcranial magnetic stimulation (TMS).^{[Sadock et al., 2009; Bauer et al., 2013]} The World Federation of…

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Major Depressive Disorder – Treatment Principles – slide 12

Brain stimulation methods – transcranial magnetic stimulation (TMS)

Other than psychotherapy, non-pharmacological therapy options for the treatment of MDD include brain stimulation methods, such as electroconvulsive therapy (ECT), vagus nerve stimulation (VNS), and transcranial magnetic stimulation (TMS).^{[Sadock et al., 2009; Bauer et al., 2013]} The World Federation of…

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Major Depressive Disorder – Treatment Principles – slide 13

Brain stimulation methods – deep brain stimulation

Other than psychotherapy, non-pharmacological therapy options for the treatment of MDD include brain stimulation methods, such as electroconvulsive therapy (ECT), vagus nerve stimulation (VNS), and transcranial magnetic stimulation (TMS).^{[Sadock et al., 2009; Bauer et al., 2013]} The World Federation of…

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