A variation to the clinical staging of AD was proposed by the National Institute on Aging – Alzheimer’s Association (NIA-AA) working group (2018) using six clinical stages for persons who are amyloid positive.

The NIA-AA Research Framework describes AD as a biological construct that can be identified in living persons via Aβ and tau biomarkers.

In the NIA-AA framework, biomarkers are used to identify the presence of AD, with clinical stages used to indicate disease severity.

Read more about New clinical staging of Alzheimer’s disease

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