Potential mechanisms by which T2DM contributes to Alzheimer’s disease

Diabetes and Alzheimer’s disease may share risk factors, including overlapping metabolic risk factors. Apolipoprotein E (APOE) also regulates lipid metabolism.¹ This suggests that the aetiology of AD includes metabolic risk factors, which are also involved in the development of diabetes.² Hyperglycaemia is the main characteristic of impaired glucose tolerance and diabetes,³ with evidence that hyperglycaemia is a potential risk factor for the development of cognitive dysfunction and dementia.⁴

Learn more about diabetes and Alzheimer’s disease