Depression is associated with reduced levels of the monoamines in the brain, such as noradrenaline. The selective noradrenaline re-uptake inhibitors (NRIs) are thought to restore the levels of noradrenaline in the synaptic cleft by binding at the noradrenaline re-uptake transporter preventing the re-uptake and subsequent degradation of noradrenaline. This re-uptake blockade leads to the accumulation of noradrenaline in the synaptic cleft and the concentration of noradrenaline returns to within the normal range. This action of NRIs is though to contribute to the alleviation of the symptoms of depression. In the presence of the NRI, small amounts of noradrenaline continue to be degraded in the synaptic cleft.

Click here: Learn about specific noradrenaline re-uptake inhibitors

file_download Download

Related content

image Image Studying Cognitive Impairment and its Neuronal Underpinnings to Predict Illness Prognosis in Bipolar Disorder
Studying Cognitive Impairment and its Neuronal Underpinnings to Predict Illness Prognosis in Bipolar Disorder

To study intra-disease variability in cognitive function, researchers employ data-driven clustering methods to differentiate patients with widespread cognitive abnormalities from patients who are cognitively intact.

05.02.2024 Mental Health
image Image The Clinical Heterogeneity in Bipolar Disorder within Several Domains.
The Clinical Heterogeneity in Bipolar Disorder within Several Domains

Bipolar disorder is associated with marked clinical and phenotypic heterogeneity, including differences in symptomatology, medical and psychiatric comorbidities, and neurocognitive function. Intra- and inter-individual differences increase the complexity of the disorder, which complicates accurate diagnosis, management.

05.02.2024 Mental Health
image Image Predominant polarity in bipolar disorder (BD) refers to the dominance of either depressive or manic episodes in an individual’s illness history.
Predominant Polarity in Bipolar Disorder

Depressive predominant polarity is typically defined as having at least two-thirds of lifetime episodes being depressive, whereas manic predominant polarity refers to at least two-thirds of prior episodes being (hypo)manic episodes. Studies show that predominant polarity has prognostic value and clinical and therapeutic implications.

05.02.2024 Mental Health