Currently, CSF p-tau181, Aβ42/40, and total tau are used to diagnose AD in clinical practice.1 P-tau217 has recently gained attention due to its high sensitivity and specificity for AD, which are both slightly higher than p-tau181. In plasma, generally speaking, the diagnostic performance of most biomarkers is lower due to difficulties in measuring very low concentrations of abnormal proteins that are present in the blood. The exception is plasma p-tau217, which has excellent diagnostic performance in plasma.2,3 In fact, plasma p-tau217 has statistically non-distinguishable performance from currently used CSF biomarkers. Therefore, plasma p-tau217 will likely have an important role in the future clinical diagnosis of Alzheimer’s disease.2,3

file_download Download

Related content

image Image Studying Cognitive Impairment and its Neuronal Underpinnings to Predict Illness Prognosis in Bipolar Disorder
Studying Cognitive Impairment and its Neuronal Underpinnings to Predict Illness Prognosis in Bipolar Disorder

To study intra-disease variability in cognitive function, researchers employ data-driven clustering methods to differentiate patients with widespread cognitive abnormalities from patients who are cognitively intact.

05.02.2024 Mental Health
image Image The Clinical Heterogeneity in Bipolar Disorder within Several Domains.
The Clinical Heterogeneity in Bipolar Disorder within Several Domains

Bipolar disorder is associated with marked clinical and phenotypic heterogeneity, including differences in symptomatology, medical and psychiatric comorbidities, and neurocognitive function. Intra- and inter-individual differences increase the complexity of the disorder, which complicates accurate diagnosis, management.

05.02.2024 Mental Health
image Image Predominant polarity in bipolar disorder (BD) refers to the dominance of either depressive or manic episodes in an individual’s illness history.
Predominant Polarity in Bipolar Disorder

Depressive predominant polarity is typically defined as having at least two-thirds of lifetime episodes being depressive, whereas manic predominant polarity refers to at least two-thirds of prior episodes being (hypo)manic episodes. Studies show that predominant polarity has prognostic value and clinical and therapeutic implications.

05.02.2024 Mental Health