The analysis shown on the slide used data from the Canadian Community Health Survey, which included 36,984 individuals, of whom 938 (2.5% of the sample) reported at least one manic episode over their lifetime.1 Compared with respondents who did not have a history of a comorbid medical disorder, people with mania and at least one comorbid medical disorder experienced a more severe prognosis, increased household/work maladjustment, reduced levels of employment, and were more frequent users of medical services.1

Reference:
1. McIntyre RS, Konarski JZ, Soczynska JK, et al. Medical comorbidity in bipolar disorder: implications for functional outcomes and health service utilization. Psychiatr Serv 2006; 57 (8): 1140–1144.