Many therapies are being studied in the treatment of bipolar disorder, including some potential treatments for the many comorbidities that can accompany the condition.5
References:
1. McLaren KD, Marangell LB. Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities. Ann Gen Hosp Psychiatry 2004; 3 (1): 7.
2. McIntyre RS, Rosenbluth M, Ramasubbu R, et al. Managing medical and psychiatric comorbidity in individuals with major depressive disorder and bipolar disorder. Ann Clin Psychiatry 2012; 24 (2): 163–169.
3. Mansur RB, Zugman A, Ahmed J, et al. Treatment with a GLP-1R agonist over four weeks promotes weight loss-moderated changes in frontal-striatal brain structures in individuals with mood disorders. Eur Neuropsychopharmacol 2017; 27 (11): 1153–1162.
4. Calkin CV, Chengappa KNR, Cairns K, et al. Treating insulin resistance with metformin as a strategy to improve clinical outcomes in treatment-resistant bipolar depression (the TRIO-BD Study): a randomized, quadruple-masked, placebo-controlled clinical trial. J Clin Psychiatry 2022; 83 (2): 21m14022.
5. ClinicalTrials.gov website. Available at www.clinicaltrials.gov.. Accessed May 2024.