Genes involved in depression

The identification of genes implicated in the development of MDD is key for elucidating the mechanisms linking genetic variation to MDD, and for finding new treatment targets in people with MDD.³ However, the complex associations of the molecular pathways determining mental health make the identification of single actionable targets for the development of new pharmacological treatments challenging.¹

References:

1. Fries GR, Saldana VA, Finnstein J, Rein T. Molecular pathways of major depressive disorder converge on the synapse. Mol Psychiatry 2023; 28 (1): 284–297.
2. Levey DF, Stein MB, Wendt FR, et al. Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions. Nat Neurosci 2021; 24 (7): 954–963.
3. Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies. Cell 2025; 188 (3): 640–652.