Major Depressive Disorder – Treatment Principles

Treatment principles

Goals of treatment

Treating depression – non-pharmacological therapies

Non-pharmacological therapy for depression

Psychotherapy – behavioural therapy

Psychotherapy – interpersonal psychotherapy

Psychotherapy – group therapy

Psychotherapy – cognitive-behavioural therapy (CBT)

Psychotherapy – mindfulness-based cognitive therapy (MBCT)

Brain stimulation methods – electroconvulsive therapy (ECT)

Brain stimulation methods – vagus nerve stimulation (VNS)

Brain stimulation methods – transcranial magnetic stimulation (TMS)

Brain stimulation methods – deep brain stimulation

Treating depression – pharmacotherapy

Overview of pharmacological therapy

Antidepressants

Definitions – use of antidepressants

Antidepressant monotherapy

Basic mechanisms of antidepressant action – reuptake inhibition and enzyme inhibition

Other mechanisms of antidepressant action – glutamate

Second-line pharmacotherapy

Strategies for patients with inadequate response

Guidelines for the treatment of depression

Treatment guidelines

Treatment guidelines (pharmacotherapy strategies) – APA

Treatment guidelines (pharmacotherapy strategies) – NICE

Treatment guidelines (pharmacotherapy strategies) – WFSBP (I)

Treatment guidelines (pharmacotherapy strategies) – WFSBP (II)

Treatment guidelines – summary of pharmacotherapy recommendations

The global approach to treatment of depression

The global approach to treatment of depression

Adverse effects of pharmacological treatment

Side effects of selected antidepressants – a rough guide

Unmet needs in the treatment of depression

Inadequate response and treatment-resistant depression

Rapid identification of non-response

Irritability and anxiety

Rapid symptom relief

Emotional blunting and anhedonia

Safety and tolerability

grid_view

out of/ 48

Slide description

The optimal outcome for a patient with major depressive disorder is a full recovery from the major depressive episode and to never become depressed again.

Full description, scroll

file_download Download slide in HQ file_downloadDownload all in HQ

The best outcome for a patient with major depressive disorder (MDD) is a full recovery from the major depressive episode and never to become depressed again. The treatment of MDD is divided into three phases, corresponding to the different stages of the illness. This slide deck includes infographic slides and figures illustrating the treatment principles of MDD, such as pharmacotherapy and non-pharmacological therapies. In addition, you will find information about the adverse effects of pharmacological treatment and unmet needs in the treatment of depression. Last, the slides present an introduction to guidelines for and a global approach to treating depression.

This slide deck has been developed in collaboration with the former Lundbeck International Neuroscience Foundation.

file_download Download slide in HQ file_downloadDownload all in HQ

Index for
slide deck

Introduction

Treatment principles

Treatment principles

The optimal outcome for a patient with major depressive disorder is a full recovery from the major depressive episode and to never become depressed again.

file_download Download slide in HQ

Goals of treatment

Goals of treatment

The optimal outcome for a patient with major depressive disorder (MDD) is a full recovery from the major depressive episode and to never become depressed again.^{[Nierenberg & DeCecco, 2001]} Treatment of MDD is divided into three phases, corresponding to different stages of…

file_download Download slide in HQ

Treating depression – non-pharmacological therapies

Treating depression – non-pharmacological therapies

Treating depression – non-pharmacological therapies

file_download Download slide in HQ

Non-pharmacological therapy for depression

Non-pharmacological therapy for depression

There are many non-pharmacological approaches to the treatment of depression. Some of those approaches are summarised in these slides.

file_download Download slide in HQ

Psychotherapy – behavioural therapy

Psychotherapy – behavioural therapy

Non-pharmacological therapy options comprise psychotherapies and brain stimulation methods. Psychotherapies may be used together with antidepressants.^{[Sadock et al., 2009]}

Generally, there is a lack of evidence surrounding the use of non-pharmacological therapies for MDD …

file_download Download slide in HQ

Psychotherapy – interpersonal psychotherapy

Psychotherapy – interpersonal psychotherapy

Non-pharmacological therapy options comprise psychotherapies and brain stimulation methods. Psychotherapies may be used together with antidepressants.^{[Sadock et al., 2009]}

Generally, there is a lack of evidence surrounding the use of non-pharmacological therapies for MDD …

file_download Download slide in HQ

Psychotherapy – group therapy

Psychotherapy – group therapy

Non-pharmacological therapy options comprise psychotherapies and brain stimulation methods. Psychotherapies may be used together with antidepressants.^{[Sadock et al., 2009]}

Generally, there is a lack of evidence surrounding the use of non-pharmacological therapies for MDD …

file_download Download slide in HQ

Psychotherapy – cognitive-behavioural therapy (CBT)

Psychotherapy – cognitive-behavioural therapy (CBT)

Non-pharmacological therapy options comprise psychotherapies and brain stimulation methods. Psychotherapies may be used together with antidepressants.^{[Sadock et al., 2009]}

Generally, there is a lack of evidence surrounding the use of non-pharmacological therapies for MDD …

file_download Download slide in HQ

Psychotherapy – mindfulness-based cognitive therapy (MBCT)

Psychotherapy – mindfulness-based cognitive therapy (MBCT)

Non-pharmacological therapy options comprise psychotherapies and brain stimulation methods. Psychotherapies may be used together with antidepressants.^{[Sadock et al., 2009]}

Generally, there is a lack of evidence surrounding the use of non-pharmacological therapies for MDD …

file_download Download slide in HQ

Brain stimulation methods – electroconvulsive therapy (ECT)

Brain stimulation methods – electroconvulsive therapy (ECT)

Other than psychotherapy, non-pharmacological therapy options for the treatment of MDD include brain stimulation methods, such as electroconvulsive therapy (ECT), vagus nerve stimulation (VNS), and transcranial magnetic stimulation (TMS). The World Federation of Societies…

file_download Download slide in HQ

Brain stimulation methods – vagus nerve stimulation (VNS)

Brain stimulation methods – vagus nerve stimulation (VNS)

Other than psychotherapy, non-pharmacological therapy options for the treatment of MDD include brain stimulation methods, such as electroconvulsive therapy (ECT), vagus nerve stimulation (VNS), and transcranial magnetic stimulation (TMS).^{[Sadock et al., 2009; Bauer et al.…}

file_download Download slide in HQ

Brain stimulation methods – transcranial magnetic stimulation (TMS)

Brain stimulation methods – transcranial magnetic stimulation (TMS)

Other than psychotherapy, non-pharmacological therapy options for the treatment of MDD include brain stimulation methods, such as electroconvulsive therapy (ECT), vagus nerve stimulation (VNS), and transcranial magnetic stimulation (TMS).^{[Sadock et al., 2009; Bauer et al.…}

file_download Download slide in HQ

Brain stimulation methods – deep brain stimulation

Brain stimulation methods – deep brain stimulation

Other than psychotherapy, non-pharmacological therapy options for the treatment of MDD include brain stimulation methods, such as electroconvulsive therapy (ECT), vagus nerve stimulation (VNS), and transcranial magnetic stimulation (TMS).^{[Sadock et al., 2009; Bauer et al.…}

file_download Download slide in HQ

task_alt