Determining the relationship between migraine and a comorbid condition is complicated. This slide deck discusses in detail the presence of comorbidity in Migraine.

This slide deck has been developed for Neurotorium in collaboration with Cambridge Medical – A Prime Global agency and Bjarke Ebert H. Lundbeck A/S. Reviewed by Clinical Research Associate Professor Henrik Winther Schytz, Danish Headache Center, Rigshospitalet Glostrup.

Index for
slide deck

Introduction

Migraine - Comorbidities
Migraine - Comorbidities
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Migraine comorbidities
Migraine comorbidities
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The comorbidities of migraine
The comorbidities of migraine

The Migraine in America Symptoms and Treatment (MAST) study was designed to evaluate patterns of migraine consultation, diagnosis, treatment and comorbid health burden among a representative non-clinical sample of people with migraine, who had an average of at least one h…

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The comorbidity burden of chronic migraine
The comorbidity burden of chronic migraine

Phase 2 of the American Migraine Prevalence and Prevention (AMPP) study was a survey of individuals with headache, of whom 11,249 had episodic migraine, and 655 had chronic migraine.[Buse et al., 2010] People with chronic migraine were significantly less likely to be empl…

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Comorbidities of migraine and migraine severity
Comorbidities of migraine and migraine severity

In the AMPP study, as shown on the slide, the prevalence of a variety of comorbid conditions increased as the number of monthly headache days (MHDs) increased.[Buse et al., 2020]

Reference:
Buse DC, Reed ML, Fanning KM, et al. Demographics, headache features, and comorbidi…

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Psychiatric comorbidities

Psychiatric comorbidities
Psychiatric comorbidities
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Psychiatric comorbidities of migraine
Psychiatric comorbidities of migraine

Determining the relationship between migraine and a comorbid condition is complicated; one cohort study aimed to examine the relationship by interviewing people with migraine (n=496), people with headaches (n=151), and people without migraine (n=539) – and then re-intervi…

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Depression
Depression

Depression is common among people with migraine – roughly 2–4 times more common than in the general population.[Amoozegar, 2017; Antonaci et al., 2011; Han et al., 2019] The comorbidity of depression and migraine increases the burden of migraine on patients and society.[A…

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Bipolar disorder
Bipolar disorder

As shown on the slide, the risk of bipolar disorder appears to be greater among people with migraine than the general population.[Leo & Singh, 2016] There also appears to be an increased risk of bipolar disorder in people with migraine with aura than for those with migrai…

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Anxiety and panic disorder
Anxiety and panic disorder

In the HADAS study, the Mini International Neuropsychiatric Interview (MINI) was administered to people with migraine without aura (n=158) and people with tension-type headache or migraine plus tension-type headache (n=110; n=106 for migraine alone).[Beghi et al., 2010] O…

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Attention deficit hyperactivity disorder (ADHD)
Attention deficit hyperactivity disorder (ADHD)

As shown on the slide, studies using prescription databases and using validated scales have shown an association between migraine and ADHD.[Arruda et al., 2020; Hansen et al., 2018; Fasmer et al., 2012] This association appears to rise throughout the third and fourth deca…

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The stigma of migraine and psychiatric comorbidity
The stigma of migraine and psychiatric comorbidity

People with migraine suffer a degree of stigma, including internalised stigma.[Seng & Seng, 2016; Young et al., 2013] Psychiatric disorders are also associated with a stigma, and so when the two conditions are comorbid, this worsens the burden of migraine.[Seng & Seng, 20…

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