Determining the relationship between migraine and a comorbid condition is complicated. This slide deck discusses in detail the presence of comorbidity in Migraine.

This slide deck has been developed for Neurotorium in collaboration with Cambridge Medical – A Prime Global agency and Bjarke Ebert H. Lundbeck A/S. Reviewed by Clinical Research Associate Professor Henrik Winther Schytz, Danish Headache Center, Rigshospitalet Glostrup.

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Index for
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Introduction

Migraine 5 Comorbidities 3 Feb 22NT Slide1
Migraine - Comorbidities
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Migraine 5 Comorbidities 3 Feb 22NT Slide2
Migraine comorbidities

Comorbidities are a feature of migraine and are explored in this slide deck.

References used on slide:Feinstein AR. The pre-therapeutic classification of co-morbidity in chronic disease. J Chronic Dis 1970; 23 (7): 455–468.

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Migraine 5 Comorbidities 3 Feb 22NT Slide3
The comorbidities of migraine

The Migraine in America Symptoms and Treatment (MAST) study was designed to evaluate patterns of migraine consultation, diagnosis, treatment and comorbid health burden among a representative non-clinical sample of people with migraine, who had an average of at least one…

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Migraine 5 Comorbidities 3 Feb 22NT Slide4
The comorbidity burden of chronic migraine

Phase 2 of the American Migraine Prevalence and Prevention (AMPP) study was a survey of individuals with headache, of whom 11,249 had episodic migraine, and 655 had chronic migraine.[Buse et al., 2010] People with chronic migraine were significantly less likely…

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Migraine 5 Comorbidities 3 Feb 22NT Slide5
Comorbidities of migraine and migraine severity

In the AMPP study, as shown on the slide, the prevalence of a variety of comorbid conditions increased as the number of monthly headache days (MHDs) increased.[Buse et al., 2020]

Reference:Buse DC, Reed ML, Fanning KM,…

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Psychiatric comorbidities

Migraine 5 Comorbidities 3 Feb 22NT Slide6
Psychiatric comorbidities
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Migraine 5 Comorbidities 3 Feb 22NT Slide7
Psychiatric comorbidities of migraine

Determining the relationship between migraine and a comorbid condition is complicated; one cohort study aimed to examine the relationship by interviewing people with migraine (n=496), people with headaches (n=151), and people without migraine (n=539) – and then re-interviewing two years…

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Migraine 5 Comorbidities 3 Feb 22NT Slide8
Depression

Depression is common among people with migraine – roughly 2–4 times more common than in the general population.[Amoozegar, 2017; Antonaci et al., 2011; Han et al., 2019] The comorbidity of depression and migraine increases the burden of migraine on patients…

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Migraine 5 Comorbidities 3 Feb 22NT Slide9
Bipolar disorder

As shown on the slide, the risk of bipolar disorder appears to be greater among people with migraine than the general population.[Leo & Singh, 2016] There also appears to be an increased risk of bipolar disorder in people with migraine…

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Migraine 5 Comorbidities 3 Feb 22NT Slide10
Anxiety and panic disorder

In the HADAS study, the Mini International Neuropsychiatric Interview (MINI) was administered to people with migraine without aura (n=158) and people with tension-type headache or migraine plus tension-type headache (n=110; n=106 for migraine alone).[Beghi et al., 2010] Of the people…

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Migraine 5 Comorbidities 3 Feb 22NT Slide11
Attention deficit hyperactivity disorder (ADHD)

As shown on the slide, studies using prescription databases and using validated scales have shown an association between migraine and ADHD.[Arruda et al., 2020; Hansen et al., 2018; Fasmer et al., 2012] This association appears to rise throughout the third…

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Migraine 5 Comorbidities 3 Feb 22NT Slide12
The stigma of migraine and psychiatric comorbidity

People with migraine suffer a degree of stigma, including internalised stigma.[Seng & Seng, 2016; Young et al., 2013] Psychiatric disorders are also associated with a stigma, and so when the two conditions are comorbid, this worsens the burden of migraine.[Seng…

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