The location of post-stroke lesions appear to be linked to the risk of cognitive impairment after stroke.1 However, different studies have highlighted that, more than the exact location of the lesion, the number of different areas of the brain affected and the brain networks affected also play a role in the development of cognitive impairment and dementia after stroke.2,3
References:
1. Weaver NA, Kuijf HJ, Aben HP, et al. Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts. Lancet Neurol 2021; 20 (6): 448–459.
2. Saczynski JS, Sigurdsson S, Jonsdottir MK, et al. Cerebral infarcts and cognitive performance: importance of location and number of infarcts. Stroke 2009; 40 (3): 677–682.
3. Lim JS, Kim N, Jang MU, et al. Cortical hubs and subcortical cholinergic pathways as neural substrates of poststroke dementia. Stroke 2014; 45 (4): 1069–1076.