Prevention of post-stroke depression with pharmacotherapy

This Cochrane analysis included 19 studies comparing an intervention (pharmacotherapy versus placebo, or psychotherapy) for the prevention of post-stroke depression that met the inclusion criteria, including 1,771 participants.¹ Of these, outcome information was available for 9 pharmacological interventions which showed a moderate positive effect of pharmacotherapy for preventing the onset of depression after stroke.¹ However, because of limitations in the design of the studies included in the analysis, the overall certainty of the evidence was rated as very low.¹

Reference:
1.Allida S, Cox KL, Hsieh CF, et al. Pharmacological, psychological and non-invasive brain stimulation interventions for preventing depression after stroke. Cochrane Database Syst Rev 2020; 5 (5): CD003689.