Treatment of post-stroke fatigue

The Cochrane review shown on the slide found eight studies which assessed efficacy on post-stroke fatigue symptoms as a primary endpoint that met the inclusion criteria, of these, six trials with seven comparisons had data suitable for meta-analysis.¹ There were five studies of pharmacotherapies (fluoxetine, enerion, (-)-OSU6162, citicoline, and Chinese herbs), and two studies of non-pharmacological interventions (a fatigue education programme, and a mindfulness-based stress reduction programme).¹ The studies were generally small studies, many with a high risk of bias, reinforcing the need for high-quality studies of interventions for post-stroke fatigue.^1,2

References:
1.Wu S, Kutlubaev MA, Chun HY, et al. Interventions for post-stroke fatigue. Cochrane Database Syst Rev 2015; 2015 (7): CD007030.

2.Aali G, Drummond A, das Nair R, Shokraneh F. Post-stroke fatigue: a scoping review. F1000Res 2020; 9: 242.

3.Mead G, Gillespie D, Barber M, et al. Post stroke intervention trial in fatigue (POSITIF): randomised multicentre feasibility trial. Clin Rehabil 2022; 36 (12): 1578–1589.