Symptoms of prodromal Parkinson’s disease

The most common prodromal symptom found in this analysis was tremor – 41% of people presented with tremor 2 years before diagnosis of PD, compared with <1% of controls.¹ In this study, the incidence of neck pain was not different between people with PD and controls.¹ The most common autonomic prodromal symptom was constipation – 32% of people presented with constipation 2 years before diagnosis, compared with 19% of controls.¹

Reference:
1.Schrag A, Horsfall L, Walters K, et al. Prediagnostic presentations of Parkinson’s disease in primary care: a case-control study. Lancet Neurol 2015; 14 (1): 57–64.