In 2024 The Lancet published two competing research-focused biological frameworks that were proposed to move the diagnosis of Parkinson’s disease beyond the presence of a combination of cardinal motor signs and symptoms.3 One of these was the SynNeurGe system, and another was the NSD-ISS system, as summarised on the slide.1,2
References:
1.Höglinger GU, Adler CH, Berg D, et al. A biological classification of Parkinson’s disease: the SynNeurGe research diagnostic criteria. Lancet Neurol 2024; 23 (2): 191–204.
2.Simuni T, Chahine LM, Poston K, et al. A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research. Lancet Neurol 2024; 23 (2): 178–190.
3.Darweesh SKL, Sampaio C, Bloem BR. Has the time come to redefine Parkinson’s disease? Lancet Neurol 2024; 23 (2): 130–133.
