As shown in an analysis of the course of PD in five groups of patients who developed the disease at different ages, from the youngest (24–53 years, left) to the oldest (73–80 years), a younger onset of PD is typically associated with a longer disease course, compared with those who develop the disease later in life.3 While the rate of progression can vary greatly between individuals during the earlier stages of PD, the late stage tends to be characterised by a more fixed and rapid progression as the disease spreads into the cortical regions of the brain.3
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