The effect of genetic subtypes of Parkinson’s disease on disease course

Compared with people with sporadic Parkinson’s disease, people with LRRK2-associated Parkinson’s disease tend to experience few cognitive and psychiatric symptoms, with slower disease progression, whereas people with GBA-associated Parkinson’s disease tend to experience an earlier onset of symptoms and faster disease progression with more cognitive and psychiatric symptoms.^1,2

References:
1.Senkevich K, Rudakou U, Gan-Or Z. New therapeutic approaches to Parkinson’s disease targeting GBA, LRRK2 and Parkin. Neuropharmacology 2022; 202: 108822.

2.Sosero YL, Gan-Or Z. LRRK2 and Parkinson’s disease: from genetics to targeted therapy. Ann Clin Transl Neurol 2023; 10 (6): 850–864.