The future of treatment for Parkinson’s disease (I)

Unlike some other diseases, PD can be managed with a range of safe and effective pharmacological and non-pharmacological treatments that allow patients to live with their disease for several years after diagnosis.^1-3 However, therapies that can prevent or delay the onset, or slow the progression of the underlying neurodegenerative disease process, remain elusive.^3-5

References:
1. Stocchi F. Conventional treatment-related motor complications: their prevention and treatment. In: Wolters & Baumann (eds). Parkinson Disease and Other Movement Disorders. VU University Press, 2014.

2. Fox SH, Katzenschlager R, Lim S-Y, et al. International Parkinson and Movement Disorder Society evidence-based medicine review: update on treatments for the motor symptoms of Parkinson’s disease. Mov Disord 2018; 33 (8): 1248–1266.

3. Wolters E, de Munter H, Steinbusch H. Parkinson’s disease. In: Wolters & Baumann (eds). Parkinson Disease and Other Movement Disorders. VU University Press, 2014.

4. Kalia LV, Kalia SK, Lang AE. Disease-modifying strategies for Parkinson’s disease. Mov Disord 2015; 30 (11): 1442–1450.

5. Mahlknecht P, Poewe W. Pharmacotherapy for disease modification in early Parkinson’s disease: how early should we be? J Parkinsons Dis 2024; 14 (s2): S407–S421.