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This meta-analysis identified 257 clinical trials from a pool of 2,374 records.[Bak et al., 2014] The analysis included raw changes in weight, change in BMI (body mass index), ≥7% weight gain, ≥7% weight loss, and a separate analysis of patients who were antipsychotic naïve on entering a study.[Bak et al., 2014] Virtually all antipsychotics appeared to cause weight gain.[Bak et al., 2014] In antipsychotic-naïve patients, this weight gain was more pronounced.[Bak et al., 2014]
Reference:
Bak M, Fransen A, Janssen J, et al. Almost all antipsychotics result in weight gain: a meta-analysis. PLOS One 2014; 9 (4): e94112.
Other references used on slide:
Llorca PM, Lançon C, Hartry A, et al. Assessing the burden of treatment-emergent adverse events associated with atypical antipsychotic medications. BMC Psychiatry 2017; 17 (1): 67.
Nasrallah HA. Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry 2008; 13 (1): 27–35.