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This was a systematic literature review of publications comparing early intervention studies with treatment as usual, in patients with first-episode psychosis, or early phase schizophrenia.[Correll et al., 2018] Early intervention studies were defined as meeting the needs of people with early-phase psychosis – a multimodal treatment program, including several psychosocial and psychopharmacological interventions, provided from one team, in a coordinated and integrated fashion.[Correll et al., 2018] Of an initial selection of 8,935 records, 10 studies were included in the final meta-analysis.[Correll et al., 2018]
From the difference highlighted by the meta-analysis, the authors conclude that early intervention programmes are clearly superior to treatment as usual across a range of clinical outcomes, including hospitalisation, symptoms, and patient functioning.[Correll et al., 2018]
Reference:
Correll CU, Galling B, Pawar A, et al. Comparison of early intervention services vs treatment as usual for early-phase psychosis: a systematic review, meta-analysis, and meta-regression. JAMA Psychiatry 2018; 75 (6): 555–565.