The analysis of the Australian Treatment Outcome Study (ATOS) data was among the first to provide meaningful insights into how long-term heroin use leads to greater healthcare system use and resource utilisation.[2,5] A sample of 428 people with heroin dependence were followed for 10–11 years, and five different treatment trajectories were modelled, ranging from ‘relapse’ to ‘long-term stability’, as shown on the slide.[2] These categories were defined based on treatment outcomes and trajectories, e.g., those in the ‘long-term success’ joint trajectory group spent fewer days in treatment than the ‘long-term stable’, ‘late success’, and ‘treatment failure’ groups; had also fewer treatment episodes, and fewer detoxification episodes.[2] Interestingly, a considerable proportion of people were able to maintain abstinence in the absence of treatment, whereas others continued opioid use in spite of treatment – although the authors keenly acknowledge the importance of treatment in recovery from heroin and opioid dependence.[2]

References:
[1] Hser YI, Evans E, Grella C, Ling W, Anglin D. Long-term course of opioid addiction. Harv Rev Psychiatry 2015; 23 (2): 76–89.

[2] Marel C, Mills KL, Slade T, et al. Modelling long-term joint trajectories of heroin use and treatment utilisation: findings from the Australian Treatment Outcome Study. EClinicalMedicine 2019; 14: 71–79.

[3] NIH HEAL website. https://heal.nih.gov/. Accessed March 2022.

[4] Baker RG, Koroshetz WJ, Volkow ND. The Helping to End Addiction Long-term (HEAL) initiative of the National Institutes of Health. JAMA 2021; 326 (11): 1005–1006.

[5] Dong H, Kerr T. Joint trajectories of heroin use and treatment utilisation: who will benefit in the long term? EClinicalMedicine 2019; 14: 7–8.