Neurocircuitry of the addiction cycle

The diagram on the slide illustrates the interaction between neurocircuitry and behaviour of addiction, divided into binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation, each of which is associated with the activation of certain neurological pathways.

References used on slide:
Sadock BJ, Sadock VA, Ruiz P (eds). Kaplan & Sadock’s Comprehensive Textbook of Psychiatry, 10th edition. Wolters Kluwer, 2017.

Volkow ND, Boyle M. Neuroscience of addiction: relevance to prevention and treatment. Am J Psychiatry 2018; 175 (8): 729–740.

Volkow ND, Koob GF, McLellan AT. Neurobiologic advances from the brain disease model of addiction. N Engl J Med 2016; 374 (4): 363–371.

Wise RA, Koob GF. The development and maintenance of drug addiction. Neuropsychopharmacology 2014; 39 (2): 254–262.