Although the interaction between drugs of abuse and the neurochemistry of the brain is increasing understood, this interaction is mediated by a complex collection of genetic, epigenetic, developmental, and psychosocial factors.[1,2] For example, it is recognised that an environment of social stress and poor social support, coupled with easy access to drugs, elevates the risk of drug use and addiction.[1] It is important to consider the interaction of the various risks of addiction when approaching the complex issues of prevention and treatment.[1]
References:
[1] Volkow ND, Michaelides M, Baler R. The neuroscience of drug reward and addiction. Physiol Rev 2019; 99 (4): 2115–2140.
[2] Camí J, Farré M. Drug addiction. N Engl J Med 2003; 349 (10): 975–986.