The blood–brain barrier (BBB) is the dynamic and complex boundary separating the circulating blood from the extracellular fluids of the brain. Importantly, the blood–brain barrier is often dysregulated in epilepsy, which may be a cause and/or consequence of eplileptic seizures. More research is needed to better understand the functioning of the blood–brain barrier in epilepsy, and help patients by developing novel therapeutic interventions.1
BBB=blood–brain barrier; BCRP=breast cancer resistance protein; CYP450=cytochrome P450; ESAM=endothelial selective adhesion molecule; JAM=junctional adhesion molecule; Pgp=P-glycoprotein
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