Depression is associated with reduced levels of the monoamines in the brain, such as serotonin (5-HT). The selective 5-HT re-uptake inhibitors (SSRIs) are thought to restore the levels of 5-HT in the synaptic cleft by binding at the 5-HT re-uptake transporter preventing the re-uptake and subsequent degradation of 5-HT. This re-uptake blockade leads to the accumulation of 5-HT in the synaptic cleft and the concentration of 5-HT returns to within the normal range. This action of SSRIs is thought to contribute to the alleviation of the symptoms of depression. In the presence of the SSRI, small amounts of 5-HT continue to be degraded in the synaptic cleft.

Click here: Explore the use of SSRIs in depression treatment

file_download Download in HQ

Related content

grid_view Slide Deck
Major depressive disorder (MDD) – Definitions and Diagnosis

This slide deck offers a comprehensive overview of Major Depressive Disorder (MDD), including its definitions, diagnostic criteria, symptom profiles, clinical course, differential diagnoses, and validated rating tools based on DSM-5-TR and ICD-11 guidelines.

02.07.2025 Depression
grid_view Slide Deck Treatment principles
Major depressive disorder (MDD) – Treatment principles

This slide deck covers the treatment principles of Major Depressive Disorder (MDD).

12.06.2025 Depression
grid_view Slide Deck
Major depressive disorder (MDD) – Course, natural history and prognosis

This slide deck covers the course, natural history, and prognosis of Major depressive disorder (MDD)

27.05.2025 Depression