The endogenous opioid system of the brain, a key system in substance use disorders and other addictions, consists of several neurotransmitters that bind in different ways to 3 different G-protein coupled receptors, called the delta (δ), mu (μ), and kappa (κ) receptors.
These 3 receptors are localised to subtly different parts of the brain, and have different physiological effects.1,2
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