In Parkinson’s Disease (PD), the disease course is often summarized as depicted in panel A. Patients develop autonomic symptoms such as constipation and REM sleep behaviour disorder (RBD) 10-20 years before diagnosis. This trajectory is however only representative of around 1/3 of PD patients, but 2/3 or more of dementia with Lewy bodies patients follow this trajectory. B. The other 2/3 of PD patients typically follow the disease course depicted in panel B. They have mild or no obvious non-motor symptoms before diagnosis. Yet, most of these patients will develop RBD, autonomic problems and other symptoms after diagnosis.
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