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  • Schizophrenia – Aetiology and neurobiology
  • Interactions between glutamate, GABA, and dopamine in schizophrenia

Interactions between glutamate, GABA, and dopamine in schizophrenia

Schizophrenia
Slide illustrating a proposed model linking glutamate, GABA, and dopamine dysfunction in schizophrenia.

References:
1. Kapur S. Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Am J Psychiatry 2003; 160: 13–23.
2. Howes OD, Bukala BR, Beck K. Schizophrenia: from neurochemistry to circuits, symptoms and treatments. Nat Rev Neurol 2024; 20: 22–35.
3. McCutcheon R, Beck K, Jauhar S, et al. Defining the locus of dopaminergic dysfunction in schizophrenia: a meta-analysis and test of the mesolimbic hypothesis. Schizophr Bull 2018; 44: 1301–1311.

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Published 23.06.2026
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