NEMESIS-2: subthreshold vs threshold anxiety

In the NEMESIS-2 study, subthreshold anxiety was defined as reporting at least 1 anxiety symptom in response to the core questions of the Composite International Diagnostic Interview for the Diagnostic and Statistical Manual of Mental Disorder (4^th edition) for panic disorder, social anxiety disorder, agoraphobia, or generalized anxiety disorder.¹ However, they did not meet the criteria for a diagnosis of anxiety in terms of severity, interference, or both.¹ At the follow-up, more than one-half of these individuals did not have any anxiety symptoms, almost 30% had persistent anxiety symptoms, and 14% had progressed to a diagnosis of an anxiety disorder.¹

Reference:
1. Bosman RC, ten Have M, de Graaf R, et al. Prevalence and course of subthreshold anxiety disorder in the general population: A three-year follow-up study. J Affect Disord 2019; 247: 105–113.