Definition of treatment refractoriness

The Delphi consensus recommendations for treatment-resistant anxiety disorders are intended as a systematic, consistent and practical guideline to define this condition and thereby aid in designing future clinical trials for regulatory purposes as well as other research projects.¹ The authors hope that the consensus recommendations will lead to the development of more effective evidence-based stepped-care treatment algorithms for patients with treatment-resistant anxiety disorders.¹

Reference:
1. Domschke K, Seuling PD, Schiele MA, et al. The definition of treatment resistance in anxiety disorders: a Delphi method-based consensus guideline. World Psychiatry 2024; 23 (1): 113–123.